Differences in placental capillary shear stress in fetal growth restriction may affect endothelial cell function and vascular network formation

Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction.

OBJECTIVE Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders. STUDY DESIGN Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions wer...

Placental Angiogenesis and Fetal Growth Restriction

Placental insufficiency and fetal growth restriction.

OBJECTIVES Fetal growth restriction is defined as a pathologic decrease in the rate of fetal growth. The most frequent etiology for late onset fetal growth restriction is uteroplacental dysfunction which is due to inadequate supply of nutrients and oxygen to support normal aerobic growth of the fetus. However, for symmetrical IUGR, fetal chromosomal anomalies, structural anomalies and fetal inf...

P-185: Expression and Function of Vascular Endothelial Growth Factor in Fallopian Tuben Carrying Ectopic Pregnancy

Background: Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that is produced by different tissues, including the endometrium and ovary. VEGF is involved in many processes related to reproductive physiology, including angiogenesis, which is essential for implantation and placentation. It has been suggested that VEGF may be the angiogenic factor responsible for the implan...

N-acetylcysteine alleviates cadmium-induced placental endoplasmic reticulum stress and fetal growth restriction in mice

Cadmium (Cd) is a developmental toxicant that induces fetal growth restriction (FGR). Placental endoplasmic reticulum (ER) stress is associated with FGR. This study investigated the effects of N-acetylcysteine (NAC) on Cd-induced placental ER stress and FGR. Pregnant mice were intraperitoneally injected with CdCl2 daily from gestational day (GD)13 to GD17. As expected, Cd reduced fetal weight a...